• Occasionally, when the cancer involves the upper gums it may be necessary to remove a portion of the sinus. The prosthodontist is again needed for reconstruction. • For larger cancers that have a lower cure rate with surgery alone, treatment combines all three methods chemotherapy , followed by surgery, followed by radiation therapy . Treatment by Location & Stage Stage I Standard Treatment • Lip: Surgery or radiotherapy , depending on cosmetic and functional results. • Front of tongue: Wide local excision . For larger lesions, either surgery or radiotherapy. • Inside of cheek: Surgery for small lesions (with skin graft, if needed) or radiotherapy for larger lesions. • Floor of mouth: Surgery or radiotherapy. • Lower gums: Surgery, possibly with removal of some bone and the use of a skin graft. Radiotherapy results are usually not as good as surgery. • Behind wisdom teeth (retromolar trigone): Can usually be controlled by external radiotherapy. Alternatively, surgical removal, including part of jawbone. • Upper gums and hard palate: Surgery, with postoperative radiation if needed.